› 3ukw

X-ray diffraction
2.1Å resolution

Mouse importin alpha: Bimax1 peptide complex

Released:
DOI: 10.2210/pdb3ukw/pdb
PDB entry 3ukw coloured by chain, front view.
PDB entry 3ukw coloured by chain, side view.
PDB entry 3ukw coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of high-affinity nuclear localization signal interactions with importin-α.
Marfori M, Lonhienne TG, Forwood JK, Kobe B
Traffic 13 532-48 (2012)
PMID: 22248489

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156506 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1 Chain: B
Molecule details ›
Chain: B
Length: 510 amino acids
Theoretical weight: 55.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 70-529; Coverage: 87%)
Gene names: Kpna2, Rch1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Bimax1 peptide Chain: C
Molecule details ›
Chain: C
Length: 28 amino acids
Theoretical weight: 3.7 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand BTB 1 x BTB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 78.561Å b: 89.493Å c: 99.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.2
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

9 review citations

Broad targeting of resistance to apoptosis in cancer.
Mohammad et al. (2015)
8 more

6 mentions without citation

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Smith et al. (2018)
5 more