› 3ulb

X-ray diffraction
1.9Å resolution

Crystal structure of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1, a TORC2 subunit, in the P212121 crystal form

Released:
DOI: 10.2210/pdb3ulb/pdb
PDB entry 3ulb coloured by chain, front view.
PDB entry 3ulb coloured by chain, side view.
PDB entry 3ulb coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.
Pan D, Matsuura Y
Acta Crystallogr Sect F Struct Biol Cryst Commun 68 386-92 (2012)
PMID: 22505404

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170619 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Target of rapamycin complex 2 subunit AVO1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 14.61 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08236 (Residues: 1056-1176; Coverage: 10%)
Gene names: AVO1, O1110, YOL078W
Sequence domains: SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P212121
Unit cell:
a: 40.775Å b: 75.701Å c: 92.231Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.214 0.27
Expression system: Escherichia coli

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Citations

3 review citations

PI3K signaling in cancer: beyond AKT.
Lien et al. (2017)
2 more

4 mentions without citation

PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains.
Gokhale et al. (2013)
3 more