› 3umn

X-ray diffraction
2Å resolution

Crystal Structure of Lamin-B1

Released:
DOI: 10.2210/pdb3umn/pdb
PDB entry 3umn coloured by chain, front view.
PDB entry 3umn coloured by chain, side view.
PDB entry 3umn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1.
Ruan J, Xu C, Bian C, Lam R, Wang JP, Kania J, Min J, Zang J
FEBS Lett 586 314-8 (2012)
PMID: 22265972

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149029 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lamin-B1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 123 amino acids
Theoretical weight: 13.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20700 (Residues: 428-550; Coverage: 21%)
Gene names: LMN2, LMNB, LMNB1
Sequence domains: Lamin Tail Domain
Structure domains: Lamin Tail domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: C222
Unit cell:
a: 107.538Å b: 169.963Å c: 53.613Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.243 0.264
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Broken nuclei--lamins, nuclear mechanics, and disease.
Davidson et al. (2014)
8 more

2 mentions without citation

Lamin A/C Mechanotransduction in Laminopathies.
Donnaloja et al. (2020)
1 more