› 3uq9

X-ray diffraction
2.34Å resolution

Adenosine kinase from Schistosoma mansoni in complex with tubercidin

Released:
DOI: 10.2210/pdb3uq9/pdb
PDB entry 3uq9 coloured by chain, front view.
PDB entry 3uq9 coloured by chain, side view.
PDB entry 3uq9 coloured by chain, top view.
Source organism: Schistosoma mansoni
Primary publication:
Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues.
Romanello L, Bachega JF, Cassago A, Brandão-Neto J, DeMarco R, Garratt RC, Pereira HD
Acta Crystallogr D Biol Crystallogr 69 126-36 (2013)
PMID: 23275171

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164132 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine kinase, putative Chains: A, B
Molecule details ›
Chains: A, B
Length: 372 amino acids
Theoretical weight: 41.61 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand TBN 3 x TBN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21212
Unit cell:
a: 59.556Å b: 180.509Å c: 78.552Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.171 0.226
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.
El Kouni MH. (2017)
1 more