› 3usb

X-ray diffraction
2.38Å resolution

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-105723 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 511 amino acids
Theoretical weight: 55.98 KDa
Source organism: Bacillus anthracis str. Ames
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A6L8P2U9 (Residues: 1-487; Coverage: 100%)
Gene names: GBAA_0008, guaB
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

4 bound ligands:
Ligand IMP 2 x IMP
Ligand SO4 2 x SO4
Ligand GOL 4 x GOL
Ligand CL 1 x CL
1 modified residue:
Ligand MSE 34 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I4
Unit cell:
a: 122.519Å b: 122.519Å c: 140.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.201
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

CBS domains: Ligand binding sites and conformational variability.
Ereño-Orbea et al. (2013)
2 more

5 mentions without citation

Redox regulation by reversible protein S-thiolation in Gram-positive bacteria.
Imber et al. (2019)
4 more