› 3uv2

X-ray diffraction
1.58Å resolution

Crystal structure of the bromodomain of human nucleosome-remodeling factor subunit BPTF

Released:
DOI: 10.2210/pdb3uv2/pdb
PDB entry 3uv2 coloured by chain, front view.
PDB entry 3uv2 coloured by chain, side view.
PDB entry 3uv2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleosome-remodeling factor subunit BPTF Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12830 (Residues: 2914-3037; Coverage: 4%)
Gene names: BPTF, FAC1, FALZ
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 7PE 1 x 7PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 27.141Å b: 66.809Å c: 39.259Å
α: 90° β: 106.16° γ: 90°
R-values:
R R work R free
0.165 0.162 0.209
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

245 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
244 more

8 mentions without citation

Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations.
Aldeghi et al. (2017)
7 more