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› 3ux7

X-ray diffraction
2.97Å resolution

Crystal structure of a dimeric myotoxic component of the Vipera ammodytes meridionalis venom reveals determinants of myotoxicity and membrane damaging activity

Released:
DOI: 10.2210/pdb3ux7/pdb
Model geometry
Fit model/data
PDB entry 3ux7 coloured by chain, front view.
PDB entry 3ux7 coloured by chain, side view.
PDB entry 3ux7 coloured by chain, top view.
Source organism: Vipera ammodytes meridionalis
Primary publication:
Crystal structure of a dimeric Ser49- PLA₂-like myotoxic component of the Vipera ammodytes meridionalis venomics reveals determinants of myotoxicity and membrane damaging activity.
Georgieva D, Coronado M, Oberthür D, Buck F, Duhalov D, Arni RK, Betzel C
Mol Biosyst 8 1405-11 (2012)
PMID: 22362132

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125037 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospholipase A2 domain-containing protein Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 122 amino acids
Theoretical weight: 13.47 KDa
Source organism: Vipera ammodytes meridionalis
UniProt:
  • Canonical: I1SB18 (Residues: 1-122; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 19 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P21
Unit cell:
a: 76.966Å b: 47.673Å c: 126.619Å
α: 90° β: 90.25° γ: 90°
R-values:
R R work R free
0.226 0.224 0.261

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Citations

2 citation in other articles

Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming.
Silva et al. (2016)
1 more