› 3uyx

X-ray diffraction
1.8Å resolution

Crystal structures of globular head of 2009 pandemic H1N1 hemagglutinin

Released:
DOI: 10.2210/pdb3uyx/pdb
PDB entry 3uyx coloured by chain, front view.
PDB entry 3uyx coloured by chain, side view.
PDB entry 3uyx coloured by chain, top view.
Source organism: Influenza A virus (A/California/04/2009(H1N1))
Primary publication:
Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines.
Xuan C, Shi Y, Qi J, Zhang W, Xiao H, Gao GF
Protein Cell 2 997-1005 (2011)
PMID: 22231357

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111237 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 24.08 KDa
Source organism: Influenza A virus (A/California/04/2009(H1N1))
Expression system: Escherichia coli
UniProt:
  • Canonical: C3W5S1 (Residues: 65-278; Coverage: 38%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin (Ha1 Chain); Chain: A; domain 1

Ligands and Environments

1 bound ligand:
Ligand NO3 2 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 46.661Å b: 75.052Å c: 60.134Å
α: 90° β: 104.17° γ: 90°
R-values:
R R work R free
0.167 0.165 0.2
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Immunogen design for HIV-1 and influenza.
Rathore et al. (2014)
4 more

3 mentions without citation

An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants.
Guest et al. (2021)
2 more