› 3v0r

X-ray diffraction
1.9Å resolution

Crystal structure of Alternaria alternata allergen Alt a 1

Released:
DOI: 10.2210/pdb3v0r/pdb
PDB entry 3v0r coloured by chain, front view.
PDB entry 3v0r coloured by chain, side view.
PDB entry 3v0r coloured by chain, top view.
Source organism: Alternaria alternata
Primary publication:
Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi.
Chruszcz M, Chapman MD, Osinski T, Solberg R, Demas M, Porebski PJ, Majorek KA, Pomés A, Minor W
J Allergy Clin Immunol 130 241-7.e9 (2012)
PMID: 22664167

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major allergen Alt a 1 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.61 KDa
Source organism: Alternaria alternata
Expression system: Escherichia coli
UniProt:
  • Canonical: P79085 (Residues: 25-157; Coverage: 96%)
Gene name: ALTA1
Sequence domains: Alternaria alternata allergen 1
Structure domains: AOC barrel-like

Ligands and Environments

4 bound ligands:
Ligand SO4 4 x SO4
Ligand UNX 4 x UNX
Ligand 0FU 3 x 0FU
Ligand 8AC 1 x 8AC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: I4122
Unit cell:
a: 70.016Å b: 70.016Å c: 179.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.167 0.19
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Mold allergens in respiratory allergy: from structure to therapy.
Twaroch et al. (2015)
12 more

10 mentions without citation

Structure of allergens and structure based epitope predictions.
Dall'antonia et al. (2014)
9 more