› 3v1t

X-ray diffraction
1.88Å resolution

Crystal structure of a putative ketoacyl reductase (FabG4) from Mycobacterium tuberculosis H37Rv at 1.9 Angstrom resolution

Released:
DOI: 10.2210/pdb3v1t/pdb
PDB entry 3v1t coloured by chain, front view.
PDB entry 3v1t coloured by chain, side view.
PDB entry 3v1t coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Dutta D, Bhattacharyya S, Das AK

Function and Biology Details

Reaction catalysed: 
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129464 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-oxoacyl-(Acyl-carrier-protein) reductase Chains: C, D
Molecule details ›
Chains: C, D
Length: 462 amino acids
Theoretical weight: 47.85 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: O53665 (Residues: 1-454; Coverage: 100%)
Gene names: MT0256, fabG-1
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P1
Unit cell:
a: 57.388Å b: 57.594Å c: 71.488Å
α: 99.24° β: 102.98° γ: 117.04°
R-values:
R R work R free
0.183 0.18 0.252
Expression system: Escherichia coli

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