› 3va1

X-ray diffraction
1.74Å resolution

Crystal structure of the mammalian MDC1 FHA domain

Released:
DOI: 10.2210/pdb3va1/pdb
PDB entry 3va1 coloured by chain, front view.
PDB entry 3va1 coloured by chain, side view.
PDB entry 3va1 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural delineation of MDC1-FHA domain binding with CHK2-pThr68.
Wu HH, Wu PY, Huang KF, Kao YY, Tsai MD
Biochemistry 51 575-7 (2012)
PMID: 22211259

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177748 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mediator of DNA damage checkpoint protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 132 amino acids
Theoretical weight: 14.59 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5PSV9 (Residues: 29-139; Coverage: 7%)
Gene names: Kiaa0170, Mdc1
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL12B2
Spacegroup: P212121
Unit cell:
a: 37.076Å b: 48.59Å c: 134.182Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.189 0.272
Expression system: Escherichia coli

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Citations

1 review citation

Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks.
Mermershtain et al. (2013)
8 other articles