› 3vbz

X-ray diffraction
1.76Å resolution

Crystal structure of Taipoxin beta subunit isoform 2

Released:
DOI: 10.2210/pdb3vbz/pdb
PDB entry 3vbz coloured by chain, front view.
PDB entry 3vbz coloured by chain, side view.
PDB entry 3vbz coloured by chain, top view.
Source organism: Oxyuranus scutellatus scutellatus
Primary publication:
Structural analysis of trimeric phospholipase A2 neurotoxin from the Australian taipan snake venom.
Cendron L, Mičetić I, Polverino de Laureto P, Paoli M
FEBS J 279 3121-35 (2012)
PMID: 22776098

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-143462 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutral phospholipase A2 homolog taipoxin beta chain 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 13.33 KDa
Source organism: Oxyuranus scutellatus scutellatus
UniProt:
  • Canonical: P0CG57 (Residues: 1-118; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 52.57Å b: 36.48Å c: 65.56Å
α: 90° β: 110.09° γ: 90°
R-values:
R R work R free
0.184 0.182 0.227

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Citations

5 review citations

Understanding the molecular mechanism underlying the presynaptic toxicity of secreted phospholipases A(2): an update.
Šribar et al. (2014)
4 more