› 3vh7

X-ray diffraction
2.02Å resolution

Structure of HIV-1 gp41 NHR/fusion inhibitor complex P21

Released:
DOI: 10.2210/pdb3vh7/pdb
PDB entry 3vh7 coloured by chain, front view.
PDB entry 3vh7 coloured by chain, side view.
PDB entry 3vh7 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structural basis of potent and broad HIV-1 fusion inhibitor CP32M.
Yao X, Chong H, Zhang C, Qiu Z, Qin B, Han R, Waltersperger S, Wang M, He Y, Cui S
J Biol Chem 287 26618-29 (2012)
PMID: 22679024

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136941 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 58 amino acids
Theoretical weight: 6.41 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P03375 (Residues: 546-588; Coverage: 5%)
Gene name: env
CP32M Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 34 amino acids
Theoretical weight: 4.3 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 50.506Å b: 45.504Å c: 55.514Å
α: 90° β: 107.65° γ: 90°
R-values:
R R work R free
0.224 0.222 0.274
Expression system: Not provided

Quick links

Citations

4 review citations

Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments.
Menéndez-Arias L. (2013)
3 more

2 mentions without citation

Structural basis of potent and broad HIV-1 fusion inhibitor CP32M.
Yao et al. (2012)
1 more