› 3vnc

X-ray diffraction
2.6Å resolution

Crystal Structure of TIP-alpha N25 from Helicobacter Pylori in its natural dimeric form

Released:
DOI: 10.2210/pdb3vnc/pdb
PDB entry 3vnc coloured by chain, front view.
PDB entry 3vnc coloured by chain, side view.
PDB entry 3vnc coloured by chain, top view.
Source organism: Helicobacter pylori 26695
Primary publication:
Crystal structure of TNF-α-inducing protein from Helicobacter pylori in active form reveals the intrinsic molecular flexibility for unique DNA-binding.
Gao M, Li D, Hu Y, Zhang Y, Zou Q, Wang DC
PLoS One 7 e41871 (2012)
PMID: 22860022

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127745 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor alpha-inducing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 168 amino acids
Theoretical weight: 19.22 KDa
Source organism: Helicobacter pylori 26695
Expression system: Escherichia coli
UniProt:
  • Canonical: O25318 (Residues: 25-192; Coverage: 88%)
Gene name: HP_0596
Sequence domains: TNF-alpha-Inducing protein of Helicobacter
Structure domains: Helicobacter TNF-alpha-Inducing protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: C2
Unit cell:
a: 138.7Å b: 46.936Å c: 99.1Å
α: 90° β: 127.78° γ: 90°
R-values:
R R work R free
0.231 0.231 0.264
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Role of TNF-α-Inducing Protein Secreted by Helicobacter pylori as a Tumor Promoter in Gastric Cancer and Emerging Preventive Strategies.
Suganuma et al. (2021)
3 other articles

2 mentions without citation

Crystal structure of TNF-α-inducing protein from Helicobacter pylori in active form reveals the intrinsic molecular flexibility for unique DNA-binding.
Gao et al. (2012)
1 more