› 3vpr

X-ray diffraction
2.27Å resolution

Crystal Structure of a TetR Family Transcriptional Regulator PfmR from Thermus thermophilus HB8

Released:
DOI: 10.2210/pdb3vpr/pdb
PDB entry 3vpr coloured by chain, front view.
PDB entry 3vpr coloured by chain, side view.
PDB entry 3vpr coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Primary publication:
Transcriptional repression mediated by a TetR family protein, PfmR, from Thermus thermophilus HB8.
Agari Y, Sakamoto K, Kuramitsu S, Shinkai A
J Bacteriol 194 4630-41 (2012)
PMID: 22753056

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176175 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 190 amino acids
Theoretical weight: 21.87 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53WD9 (Residues: 2-191; Coverage: 100%)
Gene name: TTHB023
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 20 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P21
Unit cell:
a: 49.681Å b: 57.584Å c: 133.447Å
α: 90° β: 94.01° γ: 90°
R-values:
R R work R free
0.218 0.212 0.269
Expression system: Escherichia coli

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Citations

13 citation in other articles

A specific expression profile of heat-shock proteins and glucose-regulated proteins is associated with response to neoadjuvant chemotherapy in oesophageal adenocarcinomas.
Slotta-Huspenina et al. (2013)
12 more

4 mentions without citation

Structural and functional characterization of a ketosteroid transcriptional regulator of Mycobacterium tuberculosis.
Crowe et al. (2015)
3 more