› 3vu5

X-ray diffraction
2.09Å resolution

Short peptide HIV entry Inhibitor SC22EK

Released:
DOI: 10.2210/pdb3vu5/pdb
PDB entry 3vu5 coloured by chain, front view.
PDB entry 3vu5 coloured by chain, side view.
PDB entry 3vu5 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1.
Chong H, Yao X, Qiu Z, Sun J, Zhang M, Waltersperger S, Wang M, Liu SL, Cui S, He Y
FASEB J 27 1203-13 (2013)
PMID: 23233535

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136942 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 39 amino acids
Theoretical weight: 4.49 KDa
Source organism: Human immunodeficiency virus 1
UniProt:
  • Canonical: P03375 (Residues: 553-590; Coverage: 5%)
Gene name: env
SC22 Chain: B
Molecule details ›
Chain: B
Length: 23 amino acids
Theoretical weight: 2.89 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand NH4 1 x NH4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6322
Unit cell:
a: 45.281Å b: 45.281Å c: 183.218Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.233 0.265
Expression system: Not provided

Quick links

Citations

6 review citations

Peptide entry inhibitors of enveloped viruses: the importance of interfacial hydrophobicity.
Badani et al. (2014)
5 more

1 mention without citation

Mechanism of HIV-1 Resistance to Short-Peptide Fusion Inhibitors Targeting the Gp41 Pocket.
Su et al. (2015)