› 3vwu

X-ray diffraction
3.3Å resolution

Crystal structure of peroxiredoxin 4 from M. musculus

Released:
DOI: 10.2210/pdb3vwu/pdb
PDB entry 3vwu coloured by chain, front view.
PDB entry 3vwu coloured by chain, side view.
PDB entry 3vwu coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding.
Sato Y, Kojima R, Okumura M, Hagiwara M, Masui S, Maegawa K, Saiki M, Horibe T, Suzuki M, Inaba K
Sci Rep 3 2456 (2013)
PMID: 23949117

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-4 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 255 amino acids
Theoretical weight: 28.78 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O08807 (Residues: 41-274; Coverage: 100%)
Gene name: Prdx4
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Unit cell:
a: 87.468Å b: 118.656Å c: 255.669Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.254
Expression system: Escherichia coli

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Citations

30 review citations

Oxidative protein folding: from thiol-disulfide exchange reactions to the redox poise of the endoplasmic reticulum.
Hudson et al. (2015)
29 more

3 mentions without citation

Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding.
Sato et al. (2013)
2 more