› 3vzf

X-ray diffraction
2.8Å resolution

Crystal structure of human pancreatic secretory protein ZG16p with methyl alpha-D-mannopyranoside

Released:
DOI: 10.2210/pdb3vzf/pdb
PDB entry 3vzf coloured by chain, front view.
PDB entry 3vzf coloured by chain, side view.
PDB entry 3vzf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for multiple sugar recognition of Jacalin-related human ZG16p lectin.
Kanagawa M, Liu Y, Hanashima S, Ikeda A, Chai W, Nakano Y, Kojima-Aikawa K, Feizi T, Yamaguchi Y
J Biol Chem 289 16954-65 (2014)
PMID: 24790092

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130101 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zymogen granule membrane protein 16 Chain: A
Molecule details ›
Chain: A
Length: 141 amino acids
Theoretical weight: 15.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60844 (Residues: 21-159; Coverage: 92%)
Gene name: ZG16
Sequence domains: Jacalin-like lectin domain
Structure domains: Jacalin-like lectin domain

Ligands and Environments

2 bound ligands:
Ligand MMA 1 x MMA
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P21212
Unit cell:
a: 58.192Å b: 73.045Å c: 30.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.221 0.285
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Lectin domains at the frontiers of plant defense.
Lannoo et al. (2014)
5 more

4 mentions without citation

Recognition of microbial glycans by soluble human lectins.
Wesener et al. (2017)
3 more