› 3w0d

X-ray diffraction
2.3Å resolution

Structure of elastase inhibitor AFUEI (cyrstal form I)

Released:
DOI: 10.2210/pdb3w0d/pdb
PDB entry 3w0d coloured by chain, front view.
PDB entry 3w0d coloured by chain, side view.
PDB entry 3w0d coloured by chain, top view.
Source organism: Aspergillus fumigatus Af293
Primary publication:
X-ray structure analysis and characterization of AFUEI, an elastase inhibitor from Aspergillus fumigatus.
Sakuma M, Imada K, Okumura Y, Uchiya K, Yamashita N, Ogawa K, Hijikata A, Shirai T, Homma M, Nikai T
J Biol Chem 288 17451-9 (2013)
PMID: 23640894

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175855 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Elastase inhibitor AFUEI Chains: A, B
Molecule details ›
Chains: A, B
Length: 68 amino acids
Theoretical weight: 7.53 KDa
Source organism: Aspergillus fumigatus Af293
UniProt:
  • Canonical: Q4WZ11 (Residues: 20-87; Coverage: 100%)
Gene name: AFUA_3G14940
Sequence domains: Peptidase inhibitor I78 family
Structure domains: Trypsin Inhibitor V, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P65
Unit cell:
a: 40.71Å b: 40.71Å c: 135.53Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.205 0.252

Quick links

Citations

2 review citations

Targeting eukaryotic proteases for natural products-based drug development.
Al-Awadhi et al. (2020)
1 more

1 mention without citation

X-ray structure analysis and characterization of AFUEI, an elastase inhibitor from Aspergillus fumigatus.
Sakuma et al. (2013)