› 3w0e

X-ray diffraction
1.8Å resolution

Structure of elastase inhibitor AFUEI (crystal form II)

Released:
DOI: 10.2210/pdb3w0e/pdb
PDB entry 3w0e coloured by chain, front view.
PDB entry 3w0e coloured by chain, side view.
PDB entry 3w0e coloured by chain, top view.
Source organism: Aspergillus fumigatus Af293
Primary publication:
X-ray structure analysis and characterization of AFUEI, an elastase inhibitor from Aspergillus fumigatus.
Sakuma M, Imada K, Okumura Y, Uchiya K, Yamashita N, Ogawa K, Hijikata A, Shirai T, Homma M, Nikai T
J Biol Chem 288 17451-9 (2013)
PMID: 23640894

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175855 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Elastase inhibitor AFUEI Chains: A, B
Molecule details ›
Chains: A, B
Length: 68 amino acids
Theoretical weight: 7.53 KDa
Source organism: Aspergillus fumigatus Af293
UniProt:
  • Canonical: Q4WZ11 (Residues: 20-87; Coverage: 100%)
Gene name: AFUA_3G14940
Sequence domains: Peptidase inhibitor I78 family
Structure domains: Trypsin Inhibitor V, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: R32
Unit cell:
a: 77.499Å b: 77.499Å c: 115.224Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.211 0.256

Quick links

Citations

2 review citations

The Natural Polypeptides as Significant Elastase Inhibitors.
Ahmad et al. (2020)
1 more

1 mention without citation

X-ray structure analysis and characterization of AFUEI, an elastase inhibitor from Aspergillus fumigatus.
Sakuma et al. (2013)