› 3w5c

X-ray diffraction
2.5Å resolution

Crystal structure of the calcium pump in the E2 state free from exogenous inhibitors

Released:
DOI: 10.2210/pdb3w5c/pdb
PDB entry 3w5c coloured by chain, front view.
PDB entry 3w5c coloured by chain, side view.
PDB entry 3w5c coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state.
Toyoshima C, Iwasawa S, Ogawa H, Hirata A, Tsueda J, Inesi G
Nature 495 260-4 (2013)
PMID: 23455422

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand PTY 5 x PTY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P41212
Unit cell:
a: 71.226Å b: 71.226Å c: 586.236Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.271 0.27 0.276

Quick links

Citations

22 review citations

Ca(2+) homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling.
Krebs et al. (2015)
21 more

20 mentions without citation

Role of flippases, scramblases and transfer proteins in phosphatidylserine subcellular distribution.
Hankins et al. (2015)
19 more