› 3w5d

X-ray diffraction
2.45Å resolution

Crystal structure of the calcium pump in the E2+Pi state

Released:
DOI: 10.2210/pdb3w5d/pdb
PDB entry 3w5d coloured by chain, front view.
PDB entry 3w5d coloured by chain, side view.
PDB entry 3w5d coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state.
Toyoshima C, Iwasawa S, Ogawa H, Hirata A, Tsueda J, Inesi G
Nature 495 260-4 (2013)
PMID: 23455422

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand PTY 5 x PTY
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P41212
Unit cell:
a: 71.248Å b: 71.248Å c: 587.086Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.241 0.271

Quick links

Citations

22 review citations

Ca(2+) homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling.
Krebs et al. (2015)
21 more

4 mentions without citation

Decoding P4-ATPase substrate interactions.
Roland et al. (2016)
3 more