› 3wap

X-ray diffraction
3.1Å resolution

Crystal structure of Atg13 LIR-fused human LC3C_8-125

Released:
DOI: 10.2210/pdb3wap/pdb
PDB entry 3wap coloured by chain, front view.
PDB entry 3wap coloured by chain, side view.
PDB entry 3wap coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.
Suzuki H, Tabata K, Morita E, Kawasaki M, Kato R, Dobson RC, Yoshimori T, Wakatsuki S
Structure 22 47-58 (2014)
PMID: 24290141

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-189805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated proteins 1A/1B light chain 3C Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BXW4 (Residues: 8-125; Coverage: 80%)
Gene name: MAP1LC3C
Sequence domains: Autophagy protein Atg8 ubiquitin like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P3121
Unit cell:
a: 61.73Å b: 61.73Å c: 95.881Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.207 0.273
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.
Cappadocia et al. (2018)
16 more

1 mention without citation

Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site.
Krichel et al. (2019)