› 3wbg

X-ray diffraction
2.15Å resolution

Structure of the human heart fatty acid-binding protein in complex with 1-anilinonaphtalene-8-sulphonic acid

Released:
DOI: 10.2210/pdb3wbg/pdb
PDB entry 3wbg coloured by chain, front view.
PDB entry 3wbg coloured by chain, side view.
PDB entry 3wbg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human-heart fatty-acid-binding protein 3 in complex with the fluorescent probe 1-anilinonaphthalene-8-sulphonic acid.
Hirose M, Sugiyama S, Ishida H, Niiyama M, Matsuoka D, Hara T, Mizohata E, Murakami S, Inoue T, Matsuoka S, Murata M
J Synchrotron Radiat 20 923-8 (2013)
PMID: 24121341

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, heart Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 153 amino acids
Theoretical weight: 17.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05413 (Residues: 1-133; Coverage: 100%)
Gene names: FABP11, FABP3, MDGI
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand 2AN 4 x 2AN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU, SPRING-8 BEAMLINE BL38B1
Spacegroup: C2
Unit cell:
a: 127.157Å b: 29.359Å c: 140.689Å
α: 90° β: 112.47° γ: 90°
R-values:
R R work R free
0.221 0.218 0.291
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Bioactive Structure of Membrane Lipids and Natural Products Elucidated by a Chemistry-Based Approach.
Murata et al. (2015)
10 other articles

2 mentions without citation

Impact of Intracellular Lipid Binding Proteins on Endogenous and Xenobiotic Ligand Metabolism and Disposition.
Yabut et al. (2023)
1 more