› 3wcb

X-ray diffraction
3Å resolution

Function and Biology Details

Reaction catalysed: 
(1a) 2 farnesyl diphosphate = diphosphate + presqualene diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175452 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Squalene synthase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 365 amino acids
Theoretical weight: 41.89 KDa
Source organism: Trypanosoma cruzi strain CL Brener
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4CWB4 (Residues: 25-368; Coverage: 85%)
Gene name: Tc00.1047053508369.20
Sequence domains: Squalene/phytoene synthase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

1 bound ligand:
Ligand 8PH 4 x 8PH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P212121
Unit cell:
a: 79.395Å b: 127.694Å c: 142.562Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.252
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Drug strategies targeting CYP51 in neglected tropical diseases.
Choi et al. (2014)
8 more

2 mentions without citation

Squalene synthase as a target for Chagas disease therapeutics.
Shang et al. (2014)
1 more