› 3wow

X-ray diffraction
2.5Å resolution

Crystal structure of human CK2a with AMPPNP

Released:
DOI: 10.2210/pdb3wow/pdb
PDB entry 3wow coloured by chain, front view.
PDB entry 3wow coloured by chain, side view.
PDB entry 3wow coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kinoshita T, Nakaniwa T, Sekiguchi Y, Sogabe Y, Sakurai A, Nakamura S, Nakanishi I, Shimada K, Tanaka M

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 40.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 2 x MG
Ligand ANP 1 x ANP
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P212121
Unit cell:
a: 48.242Å b: 78.46Å c: 82.389Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.184 0.24
Expression system: Escherichia coli

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