› 3wsb

X-ray diffraction
2.4Å resolution

The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole

Released:
DOI: 10.2210/pdb3wsb/pdb
PDB entry 3wsb coloured by chain, front view.
PDB entry 3wsb coloured by chain, side view.
PDB entry 3wsb coloured by chain, top view.
Source organism: Trypanosoma cruzi strain CL Brener
Entry authors: Shang N, Li Q, Huang CH, Oldfield E, Guo RT

Function and Biology Details

Reaction catalysed: 
(1a) 2 farnesyl diphosphate = diphosphate + presqualene diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175452 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Squalene synthase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 365 amino acids
Theoretical weight: 41.86 KDa
Source organism: Trypanosoma cruzi strain CL Brener
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4CWB4 (Residues: 25-368; Coverage: 85%)
Gene name: Tc00.1047053508369.20
Sequence domains: Squalene/phytoene synthase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

2 bound ligands:
Ligand FPS 4 x FPS
Ligand RWZ 4 x RWZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P212121
Unit cell:
a: 79.361Å b: 130.566Å c: 144.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.277
Expression system: Escherichia coli

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