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› 3zdr

X-ray diffraction
2.5Å resolution

Structure of the Alcohol dehydrogenase (ADH) domain of a bifunctional ADHE dehydrogenase from Geobacillus thermoglucosidasius NCIMB 11955

Released:
DOI: 10.2210/pdb3zdr/pdb
Model geometry
Fit model/data
PDB entry 3zdr coloured by chain, front view.
PDB entry 3zdr coloured by chain, side view.
PDB entry 3zdr coloured by chain, top view.
Source organism: Parageobacillus thermoglucosidasius
Primary publication:
Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius.
Extance J, Crennell SJ, Eley K, Cripps R, Hough DW, Danson MJ
Acta Crystallogr D Biol Crystallogr 69 2104-15 (2013)
PMID: 24100328

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALCOHOL DEHYDROGENASE DOMAIN OF THE BIFUNCTIONAL ACETALDEHYDE DEHYDROGENASE Chain: A
Molecule details ›
Chain: A
Length: 433 amino acids
Theoretical weight: 48.69 KDa
Source organism: Parageobacillus thermoglucosidasius
Expression system: Escherichia coli BL21
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 73.721Å b: 96.588Å c: 58.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.174 0.24
Expression system: Escherichia coli BL21

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Citations

4 review citations

Bioenergetic constraints for conversion of syngas to biofuels in acetogenic bacteria.
Bertsch et al. (2015)
3 more

10 mentions without citation

Cofactor Specificity of the Bifunctional Alcohol and Aldehyde Dehydrogenase (AdhE) in Wild-Type and Mutant Clostridium thermocellum and Thermoanaerobacterium saccharolyticum.
Zheng et al. (2015)
9 more