› 3zkt

Solution NMR

SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU- CONOTOXIN CnVA

Released:
DOI: 10.2210/pdb3zkt/pdb
PDB entry 3zkt coloured by chain, ensemble of 10 models, front view.
PDB entry 3zkt coloured by chain, ensemble of 10 models, side view.
PDB entry 3zkt coloured by chain, ensemble of 10 models, top view.
Source organism: Conus consors
Primary publication:
Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor.
Petrel C, Hocking HG, Reynaud M, Upert G, Favreau P, Biass D, Paolini-Bertrand M, Peigneur S, Tytgat J, Gilles N, Hartley O, Boelens R, Stocklin R, Servent D
Biochem Pharmacol 85 1663-71 (2013)
PMID: 23567999

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143592 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tau-conotoxin CnVA Chain: A
Molecule details ›
Chain: A
Length: 15 amino acids
Theoretical weight: 1.72 KDa
Source organism: Conus consors
Expression system: Not provided
UniProt:
  • Canonical: P0DJL6 (Residues: 1-14; Coverage: 100%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 73%
Refinement method: CYANA
Expression system: Not provided

Quick links

Citations

9 review citations

Conotoxin gene superfamilies.
Robinson et al. (2014)
8 more

1 mention without citation

Graph-Directed Approach for Downselecting Toxins for Experimental Structure Determination.
Mansbach et al. (2020)