› 3zqk

X-ray diffraction
1.7Å resolution

Von Willebrand Factor A2 domain with calcium

Released:
DOI: 10.2210/pdb3zqk/pdb
PDB entry 3zqk coloured by chain, front view.
PDB entry 3zqk coloured by chain, side view.
PDB entry 3zqk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Calcium modulates force sensing by the von Willebrand factor A2 domain.
Jakobi AJ, Mashaghi A, Tans SJ, Huizinga EG
Nat Commun 2 385 (2011)
PMID: 21750539

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
von Willebrand factor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 199 amino acids
Theoretical weight: 21.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04275 (Residues: 1477-1674; Coverage: 7%)
Gene names: F8VWF, VWF
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

3 bound ligands:
Ligand GOL 2 x GOL
Ligand CA 3 x CA
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 156.02Å b: 35.54Å c: 88.46Å
α: 90° β: 96.34° γ: 90°
R-values:
R R work R free
0.157 0.155 0.2
Expression system: Homo sapiens

Quick links

Citations

12 review citations

von Willebrand factor, Jedi knight of the bloodstream.
Springer TA. (2014)
11 more

13 mentions without citation

Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19.
Choudhary et al. (2021)
12 more