› 3zre

X-ray diffraction
2.35Å resolution

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101804 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thiol peroxidase Chain: A
Molecule details ›
Chain: A
Length: 200 amino acids
Theoretical weight: 21.4 KDa
Source organism: Yersinia pseudotuberculosis YPIII
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0H3B2F9 (Residues: 1-167; Coverage: 100%)
Gene names: YPK_1903, tpx
Sequence domains: Redoxin
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P64
Unit cell:
a: 65.008Å b: 65.008Å c: 86.284Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.235 0.233 0.273
Expression system: Escherichia coli BL21(DE3)

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Citations

6 review citations

Chemical inhibitors of the type three secretion system: disarming bacterial pathogens.
Duncan et al. (2012)
5 more

1 mention without citation

Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds.
Gabrielsen et al. (2012)