› 3zxe

X-ray diffraction
1.67Å resolution

Crystal structure of Human Galectin-7 in complex with a galactose- benzylphosphate inhibitor

Released:
DOI: 10.2210/pdb3zxe/pdb
PDB entry 3zxe coloured by chain, front view.
PDB entry 3zxe coloured by chain, side view.
PDB entry 3zxe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor.
Masuyer G, Jabeen T, Öberg CT, Leffler H, Nilsson UJ, Acharya KR
FEBS J 279 193-202 (2012)
PMID: 22059385

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155678 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 133 amino acids
Theoretical weight: 14.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47929 (Residues: 4-136; Coverage: 98%)
Gene names: LGALS7, LGALS7B, PIG1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand PGZ 2 x PGZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 35.287Å b: 53.459Å c: 138.646Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.236
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives.
Wdowiak et al. (2018)
5 more

3 mentions without citation

Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor.
Masuyer et al. (2012)
2 more