› 3zxf

X-ray diffraction
1.38Å resolution

High resolution structure of Human Galectin-7

Released:
DOI: 10.2210/pdb3zxf/pdb
PDB entry 3zxf coloured by chain, front view.
PDB entry 3zxf coloured by chain, side view.
PDB entry 3zxf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor.
Masuyer G, Jabeen T, Öberg CT, Leffler H, Nilsson UJ, Acharya KR
FEBS J 279 193-202 (2012)
PMID: 22059385

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155678 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 15.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47929 (Residues: 1-136; Coverage: 100%)
Gene names: LGALS7, LGALS7B, PIG1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
1 modified residue:
Ligand CSX 2 x CSX

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 54.301Å b: 65.11Å c: 70.832Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.226
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives.
Wdowiak et al. (2018)
5 more

4 mentions without citation

Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.
Grosset et al. (2014)
3 more