› 407d

X-ray diffraction
2.2Å resolution

STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA

Released:
DOI: 10.2210/pdb407d/pdb
PDB entry 407d coloured by chain, front view.
PDB entry 407d coloured by chain, side view.
PDB entry 407d coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA.
Kielkopf CL, White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB, Rees DC
Science 282 111-5 (1998)
PMID: 9756473

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117130 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*CP*AP*GP*TP*AP*CP*TP*GP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 10 nucleotides
Theoretical weight: 3.05 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand HP1 2 x HP1
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2
Unit cell:
a: 60.44Å b: 30.51Å c: 42.76Å
α: 90° β: 120.47° γ: 90°
R-values:
R R work R free
0.21 0.21 0.236
Expression system: Not provided

Quick links

Citations

21 review citations

Recognition of the DNA minor groove by pyrrole-imidazole polyamides.
Dervan et al. (2003)
20 more

4 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
3 more