› 411d

X-ray diffraction
1.93Å resolution

DUPLEX [5'-D(GCGTA+TACGC)]2 WITH INCORPORATED 2'-O-METHOXYETHYL RIBONUCLEOSIDE

Released:
DOI: 10.2210/pdb411d/pdb
PDB entry 411d coloured by chain, front view.
PDB entry 411d coloured by chain, side view.
PDB entry 411d coloured by chain, top view.
Source organism: Unidentified
Primary publication:
Correlating structure and stability of DNA duplexes with incorporated 2'-O-modified RNA analogues.
Tereshko V, Portmann S, Tay EC, Martin P, Natt F, Altmann KH, Egli M
Biochemistry 37 10626-34 (1998)
PMID: 9692952

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117133 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*CP*GP*TP*AP*(T39)P*AP*CP*GP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 10 nucleotides
Theoretical weight: 3.12 KDa
Source organism: Unidentified
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand T39 2 x T39

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200, null
Spacegroup: P212121
Unit cell:
a: 24.93Å b: 44.59Å c: 45.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.168 0.21
Expression system: Not provided

Quick links

Citations

8 review citations

2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation.
Manoharan M. (1999)
7 more

3 mentions without citation

Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications.
Liczner et al. (2021)
2 more