› 474d

X-ray diffraction
2.4Å resolution

A NOVEL END-TO-END BINDING OF TWO NETROPSINS TO THE DNA DECAMER D(CCCCCIIIII)2

Released:
DOI: 10.2210/pdb474d/pdb
PDB entry 474d coloured by chain, front view.
PDB entry 474d coloured by chain, side view.
PDB entry 474d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A novel end-to-end binding of two netropsins to the DNA decamers d(CCCCCIIIII)2, d(CCCBr5CCIIIII)2and d(CBr5CCCCIIIII)2.
Chen X, Mitra SN, Rao ST, Sekar K, Sundaralingam M
Nucleic Acids Res 26 5464-71 (1998)
PMID: 9826773

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117171 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*CP*CP*(CBR)P*CP*IP*IP*IP*IP*I)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 10 nucleotides
Theoretical weight: 3.05 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NT 4 x NT
1 modified residue:
Ligand CBR 4 x CBR

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 32.66Å b: 32.77Å c: 37.71Å
α: 86.01° β: 84.37° γ: 68.9°
R-values:
R R work R free
0.19 0.19 0.273
Expression system: Not provided

Quick links

Citations

2 review citations

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
1 more

1 mention without citation

C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor.
Sudhakar et al. (2018)