› 478d

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF THE B-DNA DODECAMER 5'-D(CGCGAA(TAF)TCGCG), WHERE TAF IS 2'-DEOXY-2'-FLUORO-ARABINO-FURANOSYL THYMINE

Released:
DOI: 10.2210/pdb478d/pdb
PDB entry 478d coloured by chain, front view.
PDB entry 478d coloured by chain, side view.
PDB entry 478d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Atomic-resolution crystal structures of B-DNA reveal specific influences of divalent metal ions on conformation and packing.
Minasov G, Tereshko V, Egli M
J Mol Biol 291 83-99 (1999)
PMID: 10438608

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117174 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*CP*GP*AP*AP*(TAF)P*TP*CP*GP*CP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.68 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
1 modified residue:
Ligand TAF 2 x TAF

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: R3
Unit cell:
a: 42.31Å b: 42.31Å c: 99.68Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.197 0.262
Expression system: Not provided

Quick links

Citations

13 review citations

Antibody-drug conjugates as novel anti-cancer chemotherapeutics.
Peters et al. (2015)
12 more

1 mention without citation

Sequence-based taxonomic framework for the classification of uncultured single-stranded DNA viruses of the family Genomoviridae.
Varsani et al. (2017)