› 482d

X-ray diffraction
1.54Å resolution

RELEASE OF THE CYANO MOIETY IN THE CRYSTAL STRUCTURE OF N-CYANOMETHYL-N-(2-METHOXYETHYL)-DAUNOMYCIN COMPLEXED WITH D(CGATCG)

Released:
DOI: 10.2210/pdb482d/pdb
PDB entry 482d coloured by chain, front view.
PDB entry 482d coloured by chain, side view.
PDB entry 482d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Release of the cyano moiety in the crystal structure of N-cyanomethyl-N-(2-methoxyethyl)-daunomycin complexed with d(CGATCG).
Saminadin P, Dautant A, Mondon M, Langlois D'estaintot B, Courseille C, Précigoux G
Eur J Biochem 267 457-64 (2000)
PMID: 10632715

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117177 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*AP*TP*CP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM9 1 x DM9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P41212
Unit cell:
a: 28.16Å b: 28.16Å c: 53.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.28
Expression system: Not provided

Quick links

Citations

1 citations in other articles

Restrained molecular dynamics studies on complex of adriamycin with DNA hexamer sequence d-CGATCG.
Jain et al. (2005)

2 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
1 more