› 4a0q

X-ray diffraction
1.9Å resolution

Activated Conformation of Integrin alpha1 I-Domain mutant

Released:
DOI: 10.2210/pdb4a0q/pdb
PDB entry 4a0q coloured by chain, front view.
PDB entry 4a0q coloured by chain, side view.
PDB entry 4a0q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of collagen receptor integrin α(1)I domain carrying the activating mutation E317A.
Lahti M, Bligt E, Niskanen H, Parkash V, Brandt AM, Jokinen J, Patrikainen P, Käpylä J, Heino J, Salminen TA
J Biol Chem 286 43343-51 (2011)
PMID: 22030389

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 201 amino acids
Theoretical weight: 22.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P56199 (Residues: 166-366; Coverage: 18%)
Gene name: ITGA1
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

1 bound ligand:
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P3
Unit cell:
a: 95.47Å b: 95.47Å c: 37.719Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.184 0.229
Expression system: Escherichia coli BL21

Quick links

Citations

13 citation in other articles

Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor.
Nagae et al. (2012)
12 more

3 mentions without citation

Structure of collagen receptor integrin α(1)I domain carrying the activating mutation E317A.
Lahti et al. (2011)
2 more