› 4a1n

X-ray diffraction
2.8Å resolution

Human Mitochondrial endo-exonuclease

Released:
DOI: 10.2210/pdb4a1n/pdb
PDB entry 4a1n coloured by chain, front view.
PDB entry 4a1n coloured by chain, side view.
PDB entry 4a1n coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Welin M, Moche M, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Flodin S, Graslund S, Hammarstrom M, Johansson I, Karlberg T, Kotenyova T, Nyman T, Persson C, Schuler H, Thorsell AG, Tresaugues L, Weigelt J, Nordlund P

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclease EXOG, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 335 amino acids
Theoretical weight: 37.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y2C4 (Residues: 42-368; Coverage: 89%)
Gene names: ENDOGL1, ENDOGL2, ENGL, EXOG
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand CL 2 x CL
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P3121
Unit cell:
a: 103.18Å b: 103.18Å c: 83.89Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.175 0.225
Expression system: Escherichia coli BL21(DE3)

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