› 4a47

X-ray diffraction
1.9Å resolution

Crosstalk between Cu(I) and Zn(II) homeostasis

Released:
DOI: 10.2210/pdb4a47/pdb
PDB entry 4a47 coloured by chain, front view.
PDB entry 4a47 coloured by chain, side view.
PDB entry 4a47 coloured by chain, top view.
Source organism: Synechocystis sp. PCC 6803
Primary publication:
Investigating the role of zinc and copper binding motifs of trafficking sites in the cyanobacterium Synechocystis PCC 6803.
Badarau A, Baslé A, Firbank SJ, Dennison C
Biochemistry 52 6816-23 (2013)
PMID: 24050657

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159886 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HMA domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 63 amino acids
Theoretical weight: 6.61 KDa
Source organism: Synechocystis sp. PCC 6803
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P73213 (Residues: 2-64; Coverage: 98%)
Gene name: ssr2857
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: R32
Unit cell:
a: 85.62Å b: 85.62Å c: 188.142Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.195 0.243
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 citation in other articles

Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion.
Mangini et al. (2022)
1 more

2 mentions without citation

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Hewitt et al. (2021)
1 more