Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Thrombospondin type-1 (TSP1) repeat
- Sushi/SCR/CCP domain
- Membrane attack complex component/perforin/complement C9
- Thrombospondin type-1 (TSP1) repeat superfamily
- Low-density lipoprotein (LDL) receptor class A repeat
- Membrane attack complex component/perforin (MACPF) domain
- Factor I / membrane attack complex
- Sushi/SCR/CCP superfamily
18 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
C5b6 complement complex (preferred)
PDBe Complex ID:
PDB-CPX-133869 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Complement C5
Molecule details ›
Chain: A
Length: 1580 amino acids
Theoretical weight: 177.71 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 1580 amino acids
Theoretical weight: 177.71 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P01031 (Residues: 19-1676; Coverage: 95%)
Sequence domains:
Complement component C6
Molecule details ›
Chain: B
Length: 913 amino acids
Theoretical weight: 102.54 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 913 amino acids
Theoretical weight: 102.54 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P13671 (Residues: 22-934; Coverage: 100%)
Sequence domains:
- Thrombospondin type 1 domain
- Low-density lipoprotein receptor domain class A
- MAC/Perforin domain
- Complement components C8A/B/C6, EGF-like domain
- Sushi repeat (SCR repeat)
- Kazal-type serine protease inhibitor domain
