› 4a6q

X-ray diffraction
1.5Å resolution

Crystal structure of mouse SAP18 residues 6-143

Released:
DOI: 10.2210/pdb4a6q/pdb
PDB entry 4a6q coloured by chain, front view.
PDB entry 4a6q coloured by chain, side view.
PDB entry 4a6q coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex.
Murachelli AG, Ebert J, Basquin C, Le Hir H, Conti E
Nat Struct Mol Biol 19 378-86 (2012)
PMID: 22388736

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129559 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone deacetylase complex subunit SAP18 Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 16.74 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O55128 (Residues: 6-143; Coverage: 90%)
Gene name: Sap18
Sequence domains: Sin3 associated polypeptide p18 (SAP18)
Structure domains: ASAP complex, SAP18 subunit

Ligands and Environments

2 bound ligands:
Ligand IPA 1 x IPA
Ligand MPD 1 x MPD
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: I222
Unit cell:
a: 50.368Å b: 73.631Å c: 86.704Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.211
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

The exon junction complex as a node of post-transcriptional networks.
Le Hir et al. (2016)
9 more