› 4a7n

Electron Microscopy
8.9Å resolution

Structure of bare F-actin filaments obtained from the same sample as the Actin-Tropomyosin-Myosin Complex

Released:
DOI: 10.2210/pdb4a7n/pdb
PDB entry 4a7n coloured by chain, front view.
PDB entry 4a7n coloured by chain, side view.
PDB entry 4a7n coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structure of the rigor actin-tropomyosin-myosin complex.
Behrmann E, Müller M, Penczek PA, Mannherz HG, Manstein DJ, Raunser S
Cell 150 327-38 (2012)
PMID: 22817895
Related structures: EMD-1990

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159326 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 375 amino acids
Theoretical weight: 41.88 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin

Ligands and Environments

2 bound ligands:
Ligand ADP 5 x ADP
Ligand CA 5 x CA
1 modified residue:
Ligand HIC 5 x HIC

Experiments and Validation Details

Entry percentile scores
Resolution: 8.9Å
Relevant EMDB volumes: EMD-1990

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Citations

42 review citations

Targeting the sarcomere to correct muscle function.
Hwang et al. (2015)
41 more

9 mentions without citation

Control of polarized assembly of actin filaments in cell motility.
Carlier et al. (2015)
8 more