› 4a82

Electron crystallography
2Å resolution

Fitted model of staphylococcus aureus sav1866 model ABC transporter in the human cystic fibrosis transmembrane conductance regulator volume map EMD-1966.

Released:
DOI: 10.2210/pdb4a82/pdb
PDB entry 4a82 coloured by chain, front view.
PDB entry 4a82 coloured by chain, side view.
PDB entry 4a82 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The cystic fibrosis transmembrane conductance regulator (CFTR): three-dimensional structure and localization of a channel gate.
Rosenberg MF, O'Ryan LP, Hughes G, Zhao Z, Aleksandrov LA, Riordan JR, Ford RC
J Biol Chem 286 42647-42654 (2011)
PMID: 21931164
Related structures: EMD-1966

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative multidrug export ATP-binding/permease protein SAV1866 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 578 amino acids
Theoretical weight: 64.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99T13 (Residues: 1-578; Coverage: 100%)
Gene name: SAV1866
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2Å
Relevant EMDB volumes: EMD-1966

Quick links

Citations

16 review citations

Cystic fibrosis transmembrane conductance regulator (ABCC7) structure.
Hunt et al. (2013)
15 more

4 mentions without citation

Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis.
LaRusch et al. (2014)
3 more