› 4aa6

X-ray diffraction
2.6Å resolution

The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation

Released:
DOI: 10.2210/pdb4aa6/pdb
PDB entry 4aa6 coloured by chain, front view.
PDB entry 4aa6 coloured by chain, side view.
PDB entry 4aa6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation.
Schwabe JW, Chapman L, Rhodes D
Structure 3 201-13 (1995)
PMID: 7735836

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117206 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Estrogen receptor Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 71 amino acids
Theoretical weight: 8.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 182-252; Coverage: 12%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Zinc finger, C4 type (two domains)
Structure domains: Erythroid Transcription Factor GATA-1, subunit A
5'-D(*CP*TP*AP*AP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP *CP*CP*TP*G)-3' Chains: C, G
Molecule details ›
Chains: C, G
Length: 18 nucleotides
Theoretical weight: 5.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*GP*TP*GP*AP *CP*TP*TP*A)-3' Chains: D, H
Molecule details ›
Chains: D, H
Length: 18 nucleotides
Theoretical weight: 5.51 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 8 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 121.677Å b: 113.093Å c: 62.363Å
α: 90° β: 117.45° γ: 90°
R-values:
R R work R free
0.222 0.222 not available
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

14 review citations

Estrogen receptor interaction with estrogen response elements.
Klinge CM. (2001)
13 more

3 mentions without citation

The nuclear receptor superfamily: A structural perspective.
Weikum et al. (2018)
2 more