› 4aaw

X-ray diffraction
2.2Å resolution

Function and Biology Details

Reactions catalysed: 
Acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184147 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional protein GlmU Chain: A
Molecule details ›
Chain: A
Length: 459 amino acids
Theoretical weight: 49.48 KDa
Source organism: Streptococcus pneumoniae
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q8DQ18 (Residues: 1-459; Coverage: 100%)
Gene names: glmU, spr0891
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand R84 1 x R84
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P321
Unit cell:
a: 116.779Å b: 116.779Å c: 116.683Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.237
Expression system: Escherichia coli K-12

Quick links

Citations

2 review citations

Viable screening targets related to the bacterial cell wall.
Silver LL. (2013)
1 more

1 mention without citation

The Blueprint of a Minimal Cell: MiniBacillus.
Reuß et al. (2016)