› 4ad9

X-ray diffraction
2.6Å resolution

Crystal structure of human LACTB2.

Released:
DOI: 10.2210/pdb4ad9/pdb
PDB entry 4ad9 coloured by chain, front view.
PDB entry 4ad9 coloured by chain, side view.
PDB entry 4ad9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease.
Levy S, Allerston CK, Liveanu V, Habib MR, Gileadi O, Schuster G
Nucleic Acids Res 44 1813-32 (2016)
PMID: 26826708

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176102 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endoribonuclease LACTB2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 289 amino acids
Theoretical weight: 32.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q53H82 (Residues: 1-288; Coverage: 100%)
Gene names: CGI-83, LACTB2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 12 x ZN
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 107.47Å b: 95.69Å c: 135.76Å
α: 90° β: 112.84° γ: 90°
R-values:
R R work R free
0.179 0.178 0.224
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

The process of mammalian mitochondrial protein synthesis.
Mai et al. (2017)
7 more

6 mentions without citation

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.
Pettinati et al. (2016)
5 more