› 4adg

X-ray diffraction
2.18Å resolution

Crystal structure of the Rubella virus envelope Glycoprotein E1 in post-fusion form (crystal form II)

Released:
DOI: 10.2210/pdb4adg/pdb
PDB entry 4adg coloured by chain, front view.
PDB entry 4adg coloured by chain, side view.
PDB entry 4adg coloured by chain, top view.
Source organism: Rubella virus
Primary publication:
Functional and evolutionary insight from the crystal structure of rubella virus protein E1.
DuBois RM, Vaney MC, Tortorici MA, Kurdi RA, Barba-Spaeth G, Krey T, Rey FA
Nature 493 552-6 (2013)
PMID: 23292515

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140178 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spike glycoprotein E1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 473 amino acids
Theoretical weight: 50.57 KDa
Source organism: Rubella virus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P08563 (Residues: 583-1018; Coverage: 41%)
Sequence domains: Rubella membrane glycoprotein E1
Structure domains:

Ligands and Environments

7 bound ligands:
Ligand NAG 4 x NAG
Ligand GOL 12 x GOL
Ligand CA 3 x CA
Ligand ACT 3 x ACT
Ligand CL 1 x CL
Ligand NGA 1 x NGA
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 121.68Å b: 126.55Å c: 130.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.178 0.193
Expression system: Drosophila melanogaster

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Citations

17 review citations

Viral membrane fusion.
Harrison SC. (2015)
16 more

7 mentions without citation

Molecular and Structural Insights into the Life Cycle of Rubella Virus.
Das et al. (2021)
6 more