› 4aea

X-ray diffraction
1.94Å resolution

Dimeric alpha-cobratoxin X-ray structure: Localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors

Released:
DOI: 10.2210/pdb4aea/pdb
PDB entry 4aea coloured by chain, front view.
PDB entry 4aea coloured by chain, side view.
PDB entry 4aea coloured by chain, top view.
Source organism: Naja kaouthia
Primary publication:
Dimeric α-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors.
Osipov AV, Rucktooa P, Kasheverov IE, Filkin SY, Starkov VG, Andreeva TV, Sixma TK, Bertrand D, Utkin YN, Tsetlin VI
J Biol Chem 287 6725-34 (2012)
PMID: 22223648

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-cobratoxin Chains: A, B
Molecule details ›
Chains: A, B
Length: 71 amino acids
Theoretical weight: 7.84 KDa
Source organism: Naja kaouthia
UniProt:
  • Canonical: P01391 (Residues: 1-71; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

2 bound ligands:
Ligand GLY 1 x GLY
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P3121
Unit cell:
a: 86Å b: 86Å c: 37.12Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.219 0.251

Quick links

Citations

6 review citations

Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators.
Tsetlin VI. (2015)
5 more

6 mentions without citation

Last decade update for three-finger toxins: Newly emerging structures and biological activities.
Utkin YN. (2019)
5 more